Human platelet antigens - 2013
نویسندگان
چکیده
منابع مشابه
Platelet antigens and antibodies in multitransfused patients
Abstract Background and Objectives Following incompatible blood transfusions, anti-HLA and anti- HPA antibodies may develop and cause various disorders such as post-transfusion purpura, platelet refractoriness, and thrombocytopenia leading to bleeding. The aim of this study was to investigate platelet antigens and antibodies in multi-transfused patients. Materials and Methods In this desc...
متن کاملFrequency of Human Platelet Antigens (HPA-2/3/5) Polymorphism in Iranians Evaluated by RFLP-PCR
ackground: Knowing the human platelet antigens (HPA) and genes frequency in different populations is important not only for population studies but also for clinical transfusion practice. HPA genes frequency in Iran is not evaluated, so we investigated the HPA-2, HPA-3, and HPA-5 frequency and their polymorphism. Materials and Methods: DNA from 120 Iranians (99 Iranian blood donors and 21 patie...
متن کاملHuman platelet antigens polymorphisms: Association to primary immune thrombocytopenia in the Iranian patients
Background: Human platelet antigens (HPAs) are part of platelet GP complexes have the potential to contribute to the autoantibody production. Moreover, these antigens demonstrate different patterns of distribution on different ethnic groups and variation in some types of diseases. This study was objected to determine the incidence of HPA-1 to -5 and -15 polymorphisms in the Iranians suffering f...
متن کاملHuman platelet antigens and primary immune thrombocytopenia☆
Primary immune thrombocytopenic purpura (ITP) is an acquired immune-mediated disorder characterized by transient or persistent decreased platelet count (<100 × 109/L) that affects children and adults in the absence of other underlying causes.1,2 The low platelet count results from platelet destruction by antiplatelet autoantibodies associated to causes such as insufficient platelet production, ...
متن کاملHuman platelet specific antigens and their importance.
Platelets are metabolically very active cells which support primary hemostasis and blood coagulation. Their glycocalyx layer on the external membrane contains a series of complex glycoprotein molecules, which are classified from glycoprotein-I to glycoprotein-X. The platelet membrane glycoproteins act as receptors for many adhesive proteins such as collagen, von-Willebrand factor, fibronectin, ...
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ژورنال
عنوان ژورنال: Vox Sanguinis
سال: 2013
ISSN: 0042-9007
DOI: 10.1111/vox.12085